Melita P, Belnome N A, Calbo L, Gorgone S, Palmeri R, Labruto G, Papalia E, Crescimanno C
Chir Ital. 1984 Oct;36(5):908-33.
The authors, after considering the incidence of neoplastic diseases is particularly high in subjects suffering from congenital or acquired immunologic lacks, assert the importance to perform an immunologic monitoring in the patients bearing malignant neoplasms, with the purpose to identify and calculate the direrent deficits of the sheltering organism. Then, they state the method adopted for the study of the cellulo-mediate immunity (in vivo and in vitro) and the humoral one. At last, on the basis of the results they obtained, the Authors, as a conclusion, affirm there is always in neoplastic patients a certain degree of depression of tumour immunity (especially if cellulo-mediate), and it can be put in relation to the evolutive stage of neoplasm.
作者们在考虑到先天性或后天性免疫缺陷患者患肿瘤性疾病的发生率特别高之后，断言对患有恶性肿瘤的患者进行免疫监测的重要性，目的是识别和计算宿主机体的不同缺陷。然后，他们阐述了用于研究细胞介导免疫（体内和体外）及体液免疫的方法。最后，基于所获得的结果，作者们作为结论肯定，肿瘤患者总是存在一定程度的肿瘤免疫抑制（尤其是细胞介导免疫），并且它可能与肿瘤的进展阶段有关。
