Pavoni P, Favella A, Mango L, Sciortino R, Vitale L
Eur J Nucl Med. 1977 Dec 30;2(4):247-56. doi: 10.1007/BF00252573.
Functional dynamic studies of the adrenal in vivo employing 131I-19-cholesterol were carried out as a further screening test, according to the method previously described (Pavonia and Magrini, 1977), on seven patients in whom hyperadrenocorticism was suspected on the basis of clinical symptoms. The data obtained in basal conditions, under ACTH stimulation, and under dexamethasone suppression, compared with each other and supported by the results of conventional examinations, demonstrate that the quantitative information provided by this radioisotope test is correlated with the functional state of each adrenal, thus confirming the potential value of the method for diagnostic purposes. The functional dynamic test proposed does not require a higher dose of tracer than morphologic studies and the radiation risk (approximately 2.5 rad to the ovaries or gonads) seems acceptable in adult subjects.
根据先前描述的方法（帕沃尼亚和马格里尼，1977年），对7名因临床症状怀疑患有肾上腺皮质功能亢进的患者进行了使用131I-19-胆固醇的肾上腺活体功能动态研究，作为进一步的筛查测试。在基础条件下、促肾上腺皮质激素（ACTH）刺激下和地塞米松抑制下获得的数据相互比较，并得到传统检查结果的支持，表明该放射性同位素测试提供的定量信息与每个肾上腺的功能状态相关，从而证实了该方法在诊断方面的潜在价值。所提出的功能动态测试所需的示踪剂剂量并不比形态学研究高，而且辐射风险（对卵巢或性腺约为2.5拉德）在成年受试者中似乎是可以接受的。
