Hughes C, Ecanow B
J Pharm Sci. 1984 Dec;73(12):1729-31. doi: 10.1002/jps.2600731217.
The conductivity of three xanthines (caffeine, theobromine, and theophylline) and three sugars (glucose, sucrose, and glucose-6-phosphate) was measured as part of a docusate coacervate system. The conductivity of the coacervate phase was always lower than the equilibrium phase. Conductivity of xanthines showed that caffeine had the highest conductivity, followed by theobromine and theophylline. At high concentrations, these values fell and the highest conductivity was seen in samples containing theobromine, caffeine, and theophylline. For sugars at high concentrations, the lowest values of conductivity were seen in sucrose samples. Saturated theophylline samples exhibited an increased volume in the coacervate phase volume. These findings are discussed with reference to various clinical parallels and thus supply evidence that coacervates can provide a useful model for human cytoplasm.
作为多库酯凝聚层系统的一部分，测量了三种黄嘌呤（咖啡因、可可碱和茶碱）和三种糖（葡萄糖、蔗糖和6-磷酸葡萄糖）的电导率。凝聚层相的电导率始终低于平衡相。黄嘌呤的电导率表明，咖啡因的电导率最高，其次是可可碱和茶碱。在高浓度下，这些值下降，并且在含有可可碱、咖啡因和茶碱的样品中观察到最高电导率。对于高浓度的糖，蔗糖样品的电导率值最低。饱和茶碱样品在凝聚层相体积中表现出体积增加。结合各种临床相似情况对这些发现进行了讨论，从而提供了证据表明凝聚层可以为人类细胞质提供一个有用的模型。
