Kitani H, Tsuru S, Oguchi M, Watanabe M, Zinnaka Y
J Clin Lab Immunol. 1984 Dec;15(4):211-4.
The effect of PSK on the depressed interferon (IF) production in tumor-bearing mice was studied. In tumor-bearing mice, in vitro IF production by spleen cells treated with polyinosinic-polycytidylic acid (poly I:C) was remarkably inhibited. However, these inhibitions were prevented by the intraperitoneal (ip) administration of PSK. Mice were inoculated intravenously (iv) with poly I:C-treated spleen cells, administered with PSK ip at 3 days after the tumor inoculation. When PSK was not given, poly I:C-treated spleen cells did not show an inhibitory effect on tumor growth. In mice given PSK ip, poly I:C-treated spleen cells exerted slightly inhibiting effects on tumor growth. These results suggest that PSK prevented such a modulation in tumor-bearing mice.
研究了PSK对荷瘤小鼠干扰素（IF）产生受抑制的影响。在荷瘤小鼠中，用聚肌苷酸-聚胞苷酸（poly I:C）处理的脾细胞体外产生IF受到显著抑制。然而，腹腔内（ip）给予PSK可防止这些抑制作用。给小鼠静脉内（iv）接种经poly I:C处理的脾细胞，并在肿瘤接种后3天腹腔内给予PSK。当未给予PSK时，经poly I:C处理的脾细胞对肿瘤生长未显示抑制作用。在腹腔内给予PSK的小鼠中，经poly I:C处理的脾细胞对肿瘤生长有轻微抑制作用。这些结果表明，PSK可防止荷瘤小鼠出现这种调节。
