Aksenova N N, Golosova Iu V, Fel' V Ia
Tsitologiia. 1984 Jun;26(6):729-34.
Tumor growth inhibition was compared in animals implanted a mixture of tumor cells and splenocytes, treated or non-treated with RNA preparations. The latter were isolated from the spleens of C3ha mice, both intact (control--cRNA) and immunized with normal tissues of syngeneic or allogeneic animals (immune--imRNA). Examination of various samples of splencytes of intact C3HA mice show that treatment with cRNA and imRNA preparations changes occasionally their antitumor activity in relation to MGXXIIa hepatoma cells. In the majority of the experiments effects of cRNA and imRNA on splenocytes were unidirectional. Molecular and cellular mechanisms of this phenomenon are discussed.
在植入肿瘤细胞和脾细胞混合物的动物中，比较了用RNA制剂处理或未处理时的肿瘤生长抑制情况。后者从C3ha小鼠的脾脏中分离得到，包括完整的（对照——cRNA）以及用同基因或异基因动物的正常组织免疫后的（免疫——imRNA）。对完整C3HA小鼠的各种脾细胞样本检查表明，用cRNA和imRNA制剂处理偶尔会改变它们对MGXXIIa肝癌细胞的抗肿瘤活性。在大多数实验中，cRNA和imRNA对脾细胞的作用是单向的。讨论了这种现象的分子和细胞机制。
