Ellsworth L R, Balmaceda J P, Schenken R S, Silverman A Y, Prihoda T J, Asch R H
Acta Eur Fertil. 1984 Sep-Oct;15(5):343-6.
The concentrations in follicular fluid (FF) of beta hCG, progesterone (P), estradiol (E2), androstenedione (A) and testosterone (T) by RIA were determined, in order to study the follicular micro-environment in stimulated cycles. Patients received either clomiphene with hMG plus hCG or hMG plus hCG. With increasing volume of FF (obtained at laparoscopy), P significantly increased (p less than 0.04) and hCG (p less than 0.0004) and T (p less than 0.05) significantly decreased with a borderline decrease in A (p less than 0.07). Progesterone also increased with advancing oocyte maturity. Beta-hCG and P were positively correlated with E2 and negatively correlated with A levels. It is suggested that FF hCG and progesterone levels may be markers of follicular development in stimulated cycles.
为研究促排卵周期中的卵泡微环境，采用放射免疫分析法测定了卵泡液（FF）中β-人绒毛膜促性腺激素（β-hCG）、孕酮（P）、雌二醇（E2）、雄烯二酮（A）和睾酮（T）的浓度。患者接受克罗米芬联合人绝经期促性腺激素（hMG）加hCG或hMG加hCG治疗。随着卵泡液体积（通过腹腔镜检查获得）增加，孕酮显著升高（p<0.04），hCG（p<0.0004）和睾酮（p<0.05）显著降低，雄烯二酮呈临界降低（p<0.07）。孕酮也随着卵母细胞成熟度增加而升高。β-hCG和孕酮与E2呈正相关，与A水平呈负相关。提示卵泡液中hCG和孕酮水平可能是促排卵周期中卵泡发育的标志物。
