Wied G L, Bibbo M, Pishotta F T, Bartels P H
Anal Quant Cytol. 1984 Dec;6(4):243-6.
Studies of samples from a larger patient population confirmed the consistency of expression of the previously reported markers for malignancy in normal-appearing intermediate cervical cells in samples from patients with abnormal cytology (moderate dysplasia and severe dysplasia/carcinoma in situ). Based on samples of only 30 cells per case, a false-negative rate of 10% to 30% was estimated. The expression of the marker features thus provides a clear indication of uterine abnormal cytology; the lack of expression, however, does not entirely rule out the possibility of uterine abnormalities. The use of larger sample sizes and better staining protocols could further enhance the usefulness of marker feature studies in the prescreening for cancer.
对更多患者群体样本的研究证实，在细胞学异常（中度发育异常和重度发育异常/原位癌）患者样本中，先前报道的正常外观的宫颈中层细胞恶性标志物表达具有一致性。基于每例仅30个细胞的样本，估计假阴性率为10%至30%。因此，标志物特征的表达可明确指示子宫细胞学异常；然而，缺乏表达并不能完全排除子宫异常的可能性。使用更大的样本量和更好的染色方案可进一步提高标志物特征研究在癌症预筛查中的实用性。
