Tuttle R L
Dev Biol Stand. 1977;38:189-93.
The injection of C. parvum provokes a transient cell-mediated immune response to its own bacterial antigens. During this period a subcutaneous challenge dose results in the appearance of a characteristic delayed type hypersensitivity (DTH) skin reaction. If a suspension of syngeneic tumor cells is included in this challenge, they are destroyed in immune but not control animals. Similarly, solid tumors of limited size can be made to regress under these conditions. Adoptive transfer studies revealed that, in keeping with other DTH reactions, this effect was mediated by a population of rapidly dividing, theta-bearing lymphocytes. The ramifications of this response with respect to antitumor therapy are discussed.
注射微小隐孢子虫会引发针对其自身细菌抗原的短暂细胞介导免疫反应。在此期间，皮下接种激发剂量会导致出现特征性的迟发型超敏反应（DTH）皮肤反应。如果在此激发剂量中加入同基因肿瘤细胞悬液，它们在免疫动物而非对照动物中会被破坏。同样，在这些条件下，有限大小的实体瘤也可使其消退。过继转移研究表明，与其他DTH反应一致，这种效应是由一群快速分裂的、带有θ抗原的淋巴细胞介导的。本文讨论了这种反应在抗肿瘤治疗方面的影响。
