阿扎胞苷对大鼠肝脏中酪氨酸转氨酶诱导及NAD代谢的影响。

Influence of azacytidine on the induction of tyrosine aminotransferase and the NAD metabolism in rat liver.

作者信息

Kröger H, Grätz R, Grahn H

出版信息

Int J Biochem. 1984;16(12):1387-90. doi: 10.1016/0020-711x(84)90245-3.

Abstract

5-Azacytidine was found to inhibit the induction of tyrosine aminotransferase caused by L-tyrosine and hydrocortisone. The inhibitory effect can be overcome by L-methionine. There was only a slight inhibition of the tryptophan induction by 5-azacytidine in normal animals 4 hr after the administration of tryptophan. At 8 and 12 hr, a superinduction could be observed. The NAD content in adrenalectomized animals increased after application of tryptophan and 5-azacytidine. There was a slight inhibition of ADPR transferase in the rat liver.

摘要

发现5-氮杂胞苷可抑制由L-酪氨酸和氢化可的松诱导的酪氨酸转氨酶。L-甲硫氨酸可克服这种抑制作用。在正常动物中，给予色氨酸4小时后，5-氮杂胞苷对色氨酸诱导仅有轻微抑制作用。在8小时和12小时时，可观察到超诱导现象。给予色氨酸和5-氮杂胞苷后，肾上腺切除动物的NAD含量增加。大鼠肝脏中的ADPR转移酶有轻微抑制作用。