乙醇对大鼠肝脏中酪氨酸转氨酶的引入、肝脏和大脑中NAD含量以及血清中谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶活性的影响。

Influence of ethanol upon the introduction of tyrosine aminotransferase in liver, upon the NAD content in liver and brain, and upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in the serum of rats.

作者信息

Kröger H, Grätz R, Grahn H

出版信息

Gen Pharmacol. 1985;16(1):31-5. doi: 10.1016/0306-3623(85)90266-6.

Abstract

The influence of ethanol, tryptophan, nicotinamide and methionine upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in serum as well as the induction of tyrosine aminotransferase in the liver, and of NAD+ + NADH in liver and brain are described. After oral application of 6 g/kg ethanol, the activities of the examined enzymes and the concentrations of NAD+ + NADH in the brain as well as in the liver did not change over a period of 8 hr. Administration of L-methionine lead--as is the case with DL-tryptophan--to a decrease of the NAD+ + NADH-concentration in the brain. A simultaneous application of nicotinamide, DL-tryptophan, L-methionine of l-methylnicotinamide together with ethanol caused a significant increase of the tyrosine aminotransferase induction in adrenalectomized animals. Ethanol reduced the activity of the ADPR transferase in the nuclei of rat liver cells.

摘要

本文描述了乙醇、色氨酸、烟酰胺和蛋氨酸对血清中谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶活性的影响，以及对肝脏中酪氨酸转氨酶的诱导作用，还有对肝脏和大脑中NAD⁺ + NADH的影响。口服6 g/kg乙醇后，在8小时内，所检测酶的活性以及大脑和肝脏中NAD⁺ + NADH的浓度均未发生变化。给予L-蛋氨酸（与DL-色氨酸情况相同）会导致大脑中NAD⁺ + NADH浓度降低。烟酰胺、DL-色氨酸、L-蛋氨酸或1-甲基烟酰胺与乙醇同时应用，会使去肾上腺动物的酪氨酸转氨酶诱导作用显著增强。乙醇降低了大鼠肝细胞细胞核中ADPR转移酶的活性。