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Effect of interferons on dengue virus multiplication in cultured monocytes/macrophages.

作者信息

Hotta H, Hotta S, Homma M

出版信息

Biken J. 1984 Dec;27(4):189-93.

PMID:6085674
Abstract

The effects of interferons on dengue virus multiplication in cultured human and mouse monocytes/macrophages were studied. Interferon treatment before, but not after virus inoculation suppressed virus multiplication dose-dependently. Recombinant human leukocyte A interferon was as effective as ordinary human fibroblast interferon in suppressing dengue virus multiplication in cultured human monocytes. Human monocytes, a population of non-proliferating cell lineage, maintained their interferon-mediated antiviral state for a few days after removal of the interferons.

摘要

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