Kalden J R, Leitner O, Klöckel O, Kirchner H, Manger B, Koch B
Behring Inst Mitt. 1983 May(72):193-202.
In patients with rheumatoid arthritis (RA) a significantly decreased autologous mixed lymphocyte reaction (AMLR) was observed which varied widely and did not correlate with disease activity, clinical course or treatment schedules. When supernatants of AMLR cultures were tested for the presence of soluble factors no differences were found in regard to the suppression of allogeneic and mitogen induced lymphocyte proliferation. Furthermore both test groups failed to produce detectable amounts of interferon during the course of the AMLR, in contrast to the allogeneic situation were both RA patients and normal controls exhibited a similar interferon activity in the culture supernatants.
在类风湿性关节炎（RA）患者中，观察到自体混合淋巴细胞反应（AMLR）显著降低，该反应变化很大，且与疾病活动度、临床病程或治疗方案无关。当检测AMLR培养上清液中可溶性因子的存在时，发现其对同种异体和丝裂原诱导的淋巴细胞增殖的抑制作用并无差异。此外，与同种异体情况相反，在AMLR过程中，两个测试组均未产生可检测到的干扰素量，在同种异体情况下，RA患者和正常对照在培养上清液中均表现出相似的干扰素活性。
