Bordi C, Bertelè A, Davighi M C, Pilato F, Carfagna G, Missale G
Appl Pathol. 1984;2(5):282-91.
A consecutive series of 357 endoscopic gastric biopsies was investigated after staining of histological sections with the Grimelius silver method. Argyrophil cells were classified according to the type of mucosa (fundic, antropyloric or intestinalized) in which they were located. Cases of argyrophil cell hyperplasia detectable on a qualitative basis were selected and their associations with various gastroduodenal disorders of the patients as well as with functional and pathological findings of the gastric mucosa were investigated. Hyperplasia of fundic argyrophil cells was more frequent in patients with atrophic gastritis of the fundic mucosa and a relatively well preserved antral mucosa as well as in patients with hyperplastic polyps. In contrast, it was infrequent in patients with duodenal ulcer and gastric stump. Hyperplasia of antropyloric argyrophil (non-G) cells was most frequent in patients with gastric peptic ulcer or with hyperplastic polyps as well as in those with atrophic gastritis of the fundic mucosa irrespective of the concomitant condition of antral mucosa. Hyperplasia of metaplastic argyrophil cells was more frequent in intestinal metaplasia of the antral mucosa than in that of fundic mucosa. Moreover, it was more frequent in patients with gastric cancer.
采用格里米柳斯银染法对357例连续的内镜下胃活检组织切片进行研究。嗜银细胞根据其所在黏膜类型（胃底、胃窦或肠化生）进行分类。选取定性检测可发现嗜银细胞增生的病例，研究其与患者各种胃十二指肠疾病以及胃黏膜功能和病理表现之间的关联。胃底嗜银细胞增生在胃底黏膜萎缩性胃炎且胃窦黏膜相对保存较好的患者以及增生性息肉患者中更为常见。相比之下，十二指肠溃疡和胃残端患者中则较少见。胃窦嗜银（非G）细胞增生在胃溃疡或增生性息肉患者以及胃底黏膜萎缩性胃炎患者中最为常见，无论胃窦黏膜的伴随情况如何。化生嗜银细胞增生在胃窦黏膜肠化生中比在胃底黏膜肠化生中更为常见。此外，在胃癌患者中更为常见。
