Drings P, Stiefel P, Dirks H P, Grimm V, Kleckow M, Manke H G, Queisser W, Abel U, Heinrich S
Dtsch Med Wochenschr. 1984 Jul 6;109(27):1059-64. doi: 10.1055/s-2008-1069324.
80 patients with inoperable non-small cell bronchial carcinoma were treated, at an interval of 4 weeks between them, with ifosfamide (2 g/m2 on days 1-5) and cisplatin (75 mg/m2, day 1). All diagnoses had been confirmed histologically. The course of 72 patients (36 with squamous carcinoma, 25 with adenocarcinoma, two with alveolar-cell carcinoma and nine with large-cell carcinoma) could be evaluated. There were four complete and 21 partial remissions (response rate 35%). In a further 14 patients temporary arrest of tumor growth was registered. Median survival time of all patients was 8.3 months, for those with complete and partial remission 11.5 months. Patients in whom the tumor progressed lived on average 3.9 months. Age and general state of the patients, as well as histological tumor type, had no influence on the results of treatment. Patients in stage IV lived, at seven months, significantly less long than those with only loco-regional spread (11 months). Main side-effects were vomiting, bone-marrow depression and neuropathy. Urotoxicity was not significant, as a result of treatment with mesna. Remission rate and survival time of these patients corresponded with the results obtained with other cisplatin combinations.
80例无法手术的非小细胞支气管癌患者接受了治疗，治疗间隔为4周，使用异环磷酰胺（第1 - 5天，2 g/m²）和顺铂（第1天，75 mg/m²）。所有诊断均经组织学证实。72例患者（36例鳞状细胞癌、25例腺癌、2例肺泡细胞癌和9例大细胞癌）的病程可进行评估。有4例完全缓解和21例部分缓解（缓解率35%）。另有14例患者记录到肿瘤生长暂时停止。所有患者的中位生存时间为8.3个月，完全缓解和部分缓解的患者为11.5个月。肿瘤进展的患者平均生存3.9个月。患者的年龄、一般状况以及肿瘤组织学类型对治疗结果均无影响。IV期患者的生存时间为7个月，明显短于仅局部区域扩散的患者（11个月）。主要副作用为呕吐、骨髓抑制和神经病变。由于使用了美司钠进行治疗，尿路毒性不显著。这些患者的缓解率和生存时间与其他顺铂联合方案所获得的结果相符。
