Taylor M E, Summerfield J A
FEBS Lett. 1984 Jul 23;173(1):63-6. doi: 10.1016/0014-5793(84)81018-2.
Human serum will inhibit the specific uptake of N-acetylglucosamine-terminated glycoproteins by isolated rat hepatic sinusoidal cells. The serum inhibitors are not glycoproteins that bind to the hepatic mannose/N-acetylglucosamine receptor but have the properties of lectins which bind to mannose/N-acetylglucosamine-terminated glycoproteins. They can be isolated from serum by affinity chromatography. The predominant lectin, with a molecular mass of less than 35 kDa, will inhibit the sinusoidal cell uptake of glycoproteins in vitro.
人血清会抑制分离的大鼠肝窦状细胞对 N-乙酰葡糖胺末端糖蛋白的特异性摄取。血清抑制剂不是与肝甘露糖/N-乙酰葡糖胺受体结合的糖蛋白，而是具有与甘露糖/N-乙酰葡糖胺末端糖蛋白结合的凝集素特性。它们可通过亲和层析从血清中分离出来。主要的凝集素分子量小于35 kDa，在体外会抑制窦状细胞对糖蛋白的摄取。
