Ganguly A, Weinberger M H, Guthrie G P, Fineberg N S
Hypertension. 1984 Jul-Aug;6(4):563-7. doi: 10.1161/01.hyp.6.4.563.
To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldosterone, cortisol, corticosterone, and 18-hydroxycorticosterone were measured. The results revealed a greater increase in the plasma aldosterone and 18-hydroxycorticosterone levels evoked by ACTH in the GSH group than in any other group, which suggested enhanced responsiveness of the aldosterone-producing cells to ACTH and a probable adrenal abnormality.
为研究肾上腺对促肾上腺皮质激素（ACTH）的反应，我们对正常受试者、低肾素原发性高血压（LREH）患者、原发性醛固酮增多症（PA）患者以及糖皮质激素可抑制性醛固酮增多症（GSH）患者输注了不同剂量的ACTH（1.25至20.0 mIU/30分钟）。检测了血浆醛固酮、皮质醇、皮质酮和18-羟皮质酮水平。结果显示，与其他任何组相比，GSH组中ACTH引起的血浆醛固酮和18-羟皮质酮水平升高幅度更大，这表明醛固酮生成细胞对ACTH的反应性增强以及可能存在肾上腺异常。
