Anderson R G, Wright C G, Meyerhoff W L
Int J Pediatr Otorhinolaryngol. 1984 May;7(2):91-5. doi: 10.1016/s0165-5876(84)80033-6.
Combination topical otic preparations are used to treat many infections of the external and middle ears. Despite the presence of ototoxic drugs in a number of these drops and convincing evidence of sensorineural hearing loss in humans and animal studies (Meyerhoff et al., presented at Southern Section Triological Meeting, Jan. 1983) following use of these medications, otic drops remain the cornerstone of treatment for many infectious disorders of the ear. Twelve chinchillas underwent bilateral tympanostomy tube placement and daily instillation of Cortisporin Otic Suspension (polymyxin B, neomycin, hydrocortisone, propylene glycol) in the right external auditory canal for 7 consecutive days. The animals were sacrificed 3 days later, 10 days following initiation of the Cortisporin Otic Suspension treatment. Following routine preparation of the temporal bones for light microscopy, the tissue was evaluated for evidence of inflammatory changes. All 12 animals demonstrated granulation tissue, effusion and focal hemorrhage in the ears subjected to the Cortisporin Otic Suspension. All of the contralateral control ears were normal. The present data suggest that this inflammatory response is due to a topical irritant effect of the otic preparation.
复方局部耳部制剂用于治疗许多外耳道和中耳感染。尽管许多这类滴耳剂中含有耳毒性药物，并且在人体和动物研究中（Meyerhoff等人，在1983年1月的南部地区耳鼻喉科学会会议上发表）有令人信服的证据表明使用这些药物后会出现感音神经性听力损失，但滴耳剂仍然是许多耳部感染性疾病治疗的基石。12只龙猫接受了双侧鼓膜置管，并连续7天每天向右侧外耳道滴入Cortisporin耳用混悬液（多粘菌素B、新霉素、氢化可的松、丙二醇）。在开始使用Cortisporin耳用混悬液治疗10天后，即3天后处死动物。在对颞骨进行常规光镜检查准备后，评估组织有无炎症变化迹象。所有12只动物接受Cortisporin耳用混悬液处理的耳朵均出现肉芽组织、积液和局灶性出血。所有对侧对照耳均正常。目前的数据表明，这种炎症反应是由于耳部制剂的局部刺激作用所致。
