近交系豚鼠对猪蛔虫的免疫机制。I. 细胞或血清介导的免疫被动转移
Immune mechanisms to Ascaris suum in inbred guinea-pigs. I. Passive transfer of immunity by cells or serum.
作者信息
Khoury P B, Stromberg B E, Soulsby E J
出版信息
Immunology. 1977 Apr;32(4):405-11.
Abstract
Syngeneic Strain 2 guinea-pigs which received seven s.c. injections of infective eggs of Ascaris suum were shown to harbour less larvae in their lungs than control animals after mesenteric vein challenge with 10,000 infective larvae of A. suum. Serum and cell preparations harvested from these animals were able to transfer protective immunity to normal recipients to varying degrees. Significant protection with serum preparations was obtained with immune IgG2, IgE + IgG1 and whole immune serum. Best protection with cell preparations was obtained with a pool of cells from the mesenteric, hepatic (retropancreatic), and mediastinal nodes of immune animals. Cells from the hepatic nodes of immune animals were more effective than cells from the mediastinal and mesenteric nodes. Immune spleen cells enhanced, rather than reduced, the degree of the infection. Cells or serum preparations from normal animals were not capable of transferring portective immunity to normal recipients.
摘要
接受七次皮下注射猪蛔虫感染性虫卵的同基因2系豚鼠，在经肠系膜静脉接种10,000条猪蛔虫感染性幼虫后，其肺部的幼虫数量比对照动物少。从这些动物身上采集的血清和细胞制剂能够不同程度地将保护性免疫转移给正常受体。免疫IgG2、IgE + IgG1和全免疫血清的血清制剂可获得显著保护。用来自免疫动物的肠系膜、肝（胰后）和纵隔淋巴结的细胞池进行细胞制剂处理可获得最佳保护。免疫动物肝淋巴结的细胞比纵隔和肠系膜淋巴结的细胞更有效。免疫脾细胞增强而非降低了感染程度。正常动物的细胞或血清制剂不能将保护性免疫转移给正常受体。
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本文引用的文献
1
IMMUNOLOGICAL STUDIES ON EXPERIMENTAL INFECTION OF GUINEAPIGS AND RABBITS, WITH ASCARIS SUUM GOEZE, 1782. 3. THE ANTIBODY RESPONSE IN RABBITS DEMONSTRATED BY MEANS OF THE COMPLEMENT FIXATION AND CONGLUTINATING COMPLEMENT ABSORPTION TESTS.
J Helminthol. 1964;38:325-48. doi: 10.1017/s0022149x00033897.
2
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J Helminthol. 1964;38:159-70. doi: 10.1017/s0022149x00033708.
3
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