Sato H, Tahara M, Kono M, Mizushima M, Ito J
Gan No Rinsho. 1984 Jun;30(7):843-8.
A 35-year-old woman with minute gallbladder cancer is presented. Cholecystectomy for gallstones resulted in recurrent colic lasting for a few years. Examination of the resected bladder under a dissection microscope disclosed a minute polypoid tumor with cylindroid appearance measuring 2.0 X 0.5 mm; it was located on a thin membraneous stalk in the neck region. Histologically, the tumor consisted chiefly of well-differentiated adenocarcinoma, in its periphery there were adenomatous residues; the stalk was free of neoplastic change. Blood group substances were completely absent in the cancerous tissues, they were present in adenomatous tissues. We hypothesize that the present cancer derived from the minute gallbladder adenoma via malignant change at an early stage development, suggesting a unique mode for an adenoma-carcinoma sequence in the gallbladder. The present case is believed to be the smallest cancer among reported cases and we propose to define minute gallbladder cancer as that less than 5 mm in maximum diameter.
本文报告了一例35岁的微小胆囊癌患者。因胆结石行胆囊切除术，术后反复出现绞痛数年。在解剖显微镜下检查切除的胆囊，发现一个微小的息肉样肿瘤，呈圆柱形，大小为2.0×0.5毫米；位于颈部的细膜性蒂上。组织学检查显示，肿瘤主要由高分化腺癌组成，其周边有腺瘤残留；蒂部无肿瘤性改变。癌组织中完全没有血型物质，腺瘤组织中则有。我们推测，目前的癌症是由微小胆囊腺瘤在早期发育阶段发生恶性变化而来，提示胆囊腺瘤-癌序列存在独特模式。本病例被认为是已报道病例中最小的癌症，我们建议将微小胆囊癌定义为最大直径小于5毫米的癌症。
