Scolozzi R, Boccafogli A, Tocchetto M, Salmi R, Coletti M, Vicentini L
Minerva Med. 1983 Apr 28;74(18):1021-31.
The recent literature on prognostic factors in breast cancer was examined with regard to: early or delayed diagnosis, age, menopause, tumour site and size, histological type and grading, involvement of lymph nodes, clinical stage, local recurrence, and distant metastasis. With respect to prognostic factors connected with the response to therapy, the following points were considered: menopause, involvement of lymph nodes, dimensions, clinical stage, free interval, performance and loss of weight, particular sites of metastasis, radiotherapy, oestrogen receptors, prior endocrine management, and certain body fluid parameters (haemoglobin, total lymphocytes, platelets, and white cells, albumin, LDH, SGOT, alkaline phosphatase, blood bilirubin and calcium). Radiotherapy appears to make patients less responsive to subsequent antiblastic treatment, whereas premenopausal status, good psychological and physical efficiency, and prior endocrine management seem to play a positive role in the response to chemotherapy.
对近期有关乳腺癌预后因素的文献进行了审查，涉及以下方面：早期或延迟诊断、年龄、绝经、肿瘤部位和大小、组织学类型和分级、淋巴结受累情况、临床分期、局部复发和远处转移。关于与治疗反应相关的预后因素，考虑了以下几点：绝经、淋巴结受累情况、尺寸、临床分期、无瘤间期、身体状况和体重减轻情况、转移的特定部位、放疗、雌激素受体、先前的内分泌治疗以及某些体液参数（血红蛋白、总淋巴细胞、血小板和白细胞、白蛋白、乳酸脱氢酶、谷草转氨酶、碱性磷酸酶、血胆红素和钙）。放疗似乎会使患者对后续抗增殖治疗的反应性降低，而绝经前状态、良好的心理和身体状况以及先前的内分泌治疗似乎在化疗反应中发挥积极作用。
