8-溴环鸟苷酸改善缺氧大鼠心房的能量状态。
8-bromo-cGMP improves energy state in hypoxic rat atria.
作者信息
Laustiola K, Vuorinen P, Metsä-Ketelä T
出版信息
Acta Pharmacol Toxicol (Copenh). 1984 Jul;55(1):21-4. doi: 10.1111/j.1600-0773.1984.tb01957.x.
8-bromo-cGMP (1 X 10(-4) M) was found to prevent the hypoxia-induced decrease in creatine phosphate (CrP) and ATP in isolated rat atria. An increase in ADP was also seen after 8-bromo-cGMP treatment, while the AMP level remained unchanged. 8-bromo-cGMP administration resulted in a higher energy charge during the initial state of hypoxia. 8-bromo-cGMP did not affect heart rate or contractility during hypoxia. These results suggest that cGMP improves the energy state of the heart cell in hypoxia. The exact mechanism(s) of these effects is not known but an improvement of oxidative phosphorylation might, quantitatively, account for the changes.
研究发现，8-溴环磷酸鸟苷（1×10⁻⁴ M）可防止缺氧诱导的离体大鼠心房中磷酸肌酸（CrP）和三磷酸腺苷（ATP）含量降低。8-溴环磷酸鸟苷处理后还可见二磷酸腺苷（ADP）增加，而单磷酸腺苷（AMP）水平保持不变。给予8-溴环磷酸鸟苷可使缺氧初始状态时的能荷升高。8-溴环磷酸鸟苷在缺氧期间不影响心率或心肌收缩力。这些结果表明，环磷酸鸟苷可改善缺氧时心脏细胞的能量状态。这些效应的确切机制尚不清楚，但氧化磷酸化的改善可能在数量上解释了这些变化。
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