分娩期间鞘内注射吗啡对产妇血浆β-内啡肽水平的影响。

Effect of intrathecal morphine during labor on maternal plasma beta-endorphin levels.

作者信息

Abboud T K, Goebelsmann U, Raya J, Hoffman D I, DeSousa B, Brizgys R V, Kotelko D M, Shnider S M

出版信息

Am J Obstet Gynecol. 1984 Aug 1;149(7):709-10. doi: 10.1016/0002-9378(84)90107-8.

Abstract

Plasma beta-endorphin was measured in 16 patients in labor prior to and after complete onset of analgesia with 1 mg of morphine administered intrathecally. Human beta-endorphin levels were determined by radioimmunoassay following silicic acid extraction of plasma samples and separation of the beta-endorphin fraction by gel chromatography. Plasma beta-endorphin levels decreased significantly (p less than 0.005) after intrathecal morphine from 76 +/- 9.7 to 46.3 +/- 9.1 fmol/ml (mean +/- SE), possibly because of decreased pituitary beta-endorphin secretion in response to alleviation of labor pain.

摘要

对16名分娩期患者在鞘内注射1毫克吗啡达到完全镇痛前后测定血浆β-内啡肽。血浆样本经硅酸萃取并用凝胶色谱法分离出β-内啡肽组分后，通过放射免疫测定法测定人β-内啡肽水平。鞘内注射吗啡后，血浆β-内啡肽水平显著下降（p<0.005），从76±9.7降至46.3±9.1 fmol/ml（平均值±标准误），这可能是由于分娩疼痛缓解后垂体β-内啡肽分泌减少所致。