Okerlund M D, Sheldon K, Corpuz S, O'Connell W, Faulkner D, Clark O, Galante M
Ann Surg. 1984 Sep;200(3):381-8. doi: 10.1097/00000658-198409000-00016.
A novel method for localization of abnormal parathyroid glands involving color-processing of nuclear scintigrams of the neck after injection of Thallium-201 and Technetium pertechnetate is presented with surgical correlation. Preoperative localization of single parathyroid adenomas was successful in 88% of previously unoperated patients and in 85.7% of those with adenomas not located at previous surgery. Eighty-three per cent of glands with secondary hyperplasia, 66% of glands with primary hyperplasia, and one carcinoma were localized. No abnormal studies were seen in non-hyperparathyroid hypercalcemia, and no false positive studies were seen. Localization appeared related to larger adenomas (300-5000 mg), although one of 60 mg was localized. Color-comparison dual-isotype scintigraphy was useful for localization of parathyroid adenomas and hyperplastic glands and exceeded the reported sensitivity of either ultrasonography or computerized tomography. It deserves wider evaluation in preoperative management of at least hyperparathyroidism of the primary or persistent types.
本文介绍了一种用于异常甲状旁腺定位的新方法，该方法涉及在注射铊-201和高锝酸盐后对颈部核闪烁图进行颜色处理，并与手术结果相关联。术前对单发甲状旁腺腺瘤的定位在88%既往未接受过手术的患者以及85.7%既往手术未发现腺瘤的患者中取得成功。83%的继发性增生腺体、66%的原发性增生腺体以及1例癌得以定位。在非甲状旁腺功能亢进性高钙血症患者中未发现异常检查结果，也未出现假阳性检查结果。定位似乎与较大的腺瘤（300 - 5000毫克）有关，尽管有一个60毫克的腺瘤也被定位。颜色对比双同位素闪烁扫描对甲状旁腺腺瘤和增生腺体的定位很有用，其敏感性超过了报道的超声或计算机断层扫描的敏感性。它在至少原发性或持续性甲状旁腺功能亢进的术前管理中值得进行更广泛的评估。
