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维生素D3活性代谢产物作为运动不足大鼠钙磷代谢紊乱的一种应对措施。

Vitamin D3 active metabolites as a countermeasure against disorders of calcium-phosphorus metabolism in hypokinetic rats.

作者信息

Ushakov A S, Spirichev V B, Belakovsky M S, Sergeev I N, Kaplansky A S, Shvets V N

出版信息

Aviat Space Environ Med. 1984 Jun;55(6):534-7.

PMID:6087784
Abstract

Male Wistar rats that were experimentally hypokinetic were fed 24,25(OH)2D3 or 1,25(OH)2D3 separately or in combination to determine the effect on bone growth and on bone formation and resorption. It was shown that these parameters of bone metabolism are influenced by these metabolites of vitamin D3 by their effect on bone sensitivity to their activity and perhaps in the regulation of bone histogenesis.

摘要

对实验性运动不足的雄性Wistar大鼠分别或联合喂食24,25(OH)₂D₃或1,25(OH)₂D₃,以确定其对骨骼生长以及骨形成和骨吸收的影响。结果表明,骨代谢的这些参数受维生素D₃的这些代谢产物影响,其作用机制可能是影响骨骼对其活性的敏感性,或许还参与了骨组织发生的调节。

相似文献

1
Vitamin D3 active metabolites as a countermeasure against disorders of calcium-phosphorus metabolism in hypokinetic rats.维生素D3活性代谢产物作为运动不足大鼠钙磷代谢紊乱的一种应对措施。
Aviat Space Environ Med. 1984 Jun;55(6):534-7.
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[Effect of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on growth and remodeling of rat bones during hypokinesia (histomorphometric study)].
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[Comparative study of the effect of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on calcium homeostasis and bone tissue state in rats during hypokinesia].
Vopr Med Khim. 1987 Jan-Feb;33(1):100-7.
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[Calcium metabolism and the level of active metabolites of vitamin D3 in the rat serum during bone regeneration].[大鼠骨再生过程中的钙代谢及血清中维生素D3活性代谢产物水平]
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[Metabolism of 25-hydroxyvitamin D3 and its regulation in rats during hypokinesis].[大鼠运动减少期间25-羟基维生素D3的代谢及其调节]
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Maturation-dependent regulation of protein kinase C activity by vitamin D3 metabolites in chondrocyte cultures.维生素D3代谢产物对软骨细胞培养物中蛋白激酶C活性的成熟依赖性调节。
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Effects of vitamin D3 dihydroxylated metabolites on parathyroid hormone in the rat. 'In vitro' studies with dispersed rat parathyroid cells.维生素D3二羟基化代谢产物对大鼠甲状旁腺激素的影响。大鼠甲状旁腺分散细胞的“体外”研究。
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[Comparative study of the effects of alpha-25-dihydroxycholecalciferol and 24, 25-dihydroxycholecalciferol on calcium-phosphorus metabolism and on bone tissue in experimental kidney insufficiency in rats].[α-25-二羟胆钙化醇与24,25-二羟胆钙化醇对大鼠实验性肾功能不全时钙磷代谢及骨组织影响的比较研究]
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