Braunstein K M, Eurenius K
Am J Clin Pathol. 1976 Sep;66(3):488-94. doi: 10.1093/ajcp/66.3.488.
An assay technic for measuring heparin cofactor activity in which antithrombin activity can be assessed without plasma attenuation even in the presence of therapeutic levels of heparin is presented. Heparin-activated anti-thrombin activity was markedly depressed in plasmas of four patients with disseminated intravascular coagulation and in ten patients with cirrhosis. Residual activity in those plasmas appeared qualitatively normal, and no inhibitor (platelet factor IV activity) was observed. Plasmas from patients with disseminated intravascular coagulation and cirrhosis required more heparin to obtain in vitro clotting time prolongation equivalent to normal.
本文介绍了一种测量肝素辅因子活性的检测技术，即使在存在治疗水平肝素的情况下，也能在不使血浆稀释的情况下评估抗凝血酶活性。在4例弥散性血管内凝血患者和10例肝硬化患者的血浆中，肝素激活的抗凝血酶活性显著降低。这些血浆中的残余活性在质量上似乎正常，未观察到抑制剂（血小板因子IV活性）。弥散性血管内凝血和肝硬化患者的血浆需要更多的肝素才能在体外获得与正常水平相当的凝血时间延长。
