Gallin J I, Seligmann B E
Fed Proc. 1984 Sep;43(12):2732-6.
Neutrophil responsiveness to N-formylmethionylleucylphenylalanine (fMet-Leu-Phe) appears to involve either receptor recycling and/or a storage pool of receptors that provide a mechanism for replenishment of receptors at the cell surface. Asymmetric distribution of the fMet-Leu-Phe receptor has been shown by others, with increased receptor density reported at the front of the cell. This receptor asymmetry may result from receptor capping in the front, receptor internalization or shedding in the rear, or addition of new receptors at the front of the cell. In addition to receptor asymmetry, affinity adaptation of the receptor through heterogeneity and/or negative cooperative interaction of the receptors is probably important. It has been suggested that a high-affinity state of the receptor is associated with transduction of chemotaxis and a low-affinity state with transduction of superoxide production and degranulation. Thus, the fMet-Leu-Phe receptor is an important model to study how neutrophils recognize and integrate signals for their complex functions.
中性粒细胞对N-甲酰甲硫氨酰亮氨酰苯丙氨酸（fMet-Leu-Phe）的反应似乎涉及受体循环利用和/或受体储存库，这为细胞表面受体的补充提供了一种机制。其他人已经证明了fMet-Leu-Phe受体的不对称分布，据报道细胞前端的受体密度增加。这种受体不对称可能是由于前端的受体成帽、后端的受体内化或脱落，或者是细胞前端添加了新的受体。除了受体不对称外，受体通过异质性和/或受体的负协同相互作用进行亲和力适应可能也很重要。有人提出，受体的高亲和力状态与趋化性转导有关，而低亲和力状态与超氧化物产生和脱颗粒转导有关。因此，fMet-Leu-Phe受体是研究中性粒细胞如何识别和整合其复杂功能信号的重要模型。
