Matthaei D, Kramer P, Langescheid C, McIntosh C, Schwinn G, Ebert R, Arnold R, Schauder G, Scheler F
J Dial. 1977;1(6):641-9. doi: 10.3109/08860227709037659.
The concentrations of testosterone, cortisone, gastrin, GIP, somatomedin B, insulin, HGH, and TSH have been determined in the plasma and the ultrafiltrate of five uremic patients undergoing intermittent hemofiltration treatment. There was a considerable loss of gastrin, GIP, somatomedin B, and insulin by hemofiltration treatment; the plasma concentrations, however, did not decrease. Cortisone, HGH, and TSH were not detectable in the ultrafiltrate. Our results therefore indicate that hemofiltration does not cause a hormone deficiency syndrome. On the contrary, the loss of degradation products of hormones with disturbing biological activity may be a favourable effect of the hemofiltration treatment.
已测定了五名接受间歇性血液滤过治疗的尿毒症患者血浆和超滤液中睾酮、可的松、胃泌素、胃抑肽、生长调节素B、胰岛素、生长激素和促甲状腺激素的浓度。血液滤过治疗导致胃泌素、胃抑肽、生长调节素B和胰岛素大量丢失；然而，血浆浓度并未降低。超滤液中未检测到可的松、生长激素和促甲状腺激素。因此，我们的结果表明血液滤过不会导致激素缺乏综合征。相反，具有干扰生物活性的激素降解产物的丢失可能是血液滤过治疗的一个有利效果。
