Reyes-Vazquez C, Weisbrodt N, Dafny N
Life Sci. 1984 Aug 27;35(9):1015-21. doi: 10.1016/0024-3205(84)90668-4.
It had been reported that alpha interferon (alpha-IFN) induces endorphin-like effects such as analgesia and catatonia. These effects, reversed and prevented by naloxone, suggest that the alpha-IFN effect is mediated via opiate receptors. In order to examine this hypothesis, the present study was initiated. Extracellular cortical cell recording and microiontophoretic application of alpha-IFN, morphine, and naloxone, as well as the application of these three drugs on the coaxially stimulated guinea-pig ileum preparation were used. alpha-IFN application induced excitation in cortical cells and on the guinea-pig ileum. In contrast, the main effect elicited by morphine was a decrease in both preparations. Naloxone was able to reverse and/or prevent the morphine effects in both preparations, but failed to alter the effects induced by alpha-IFN. The present observations using the guinea-pig ileum preparation and cortical neurons recording failed to support the hypothesis that alpha-IFN effects are mediated via opiate receptors.
据报道，α干扰素（α-IFN）可诱导内啡肽样效应，如镇痛和紧张症。这些效应可被纳洛酮逆转和预防，提示α-IFN的效应是通过阿片受体介导的。为了检验这一假设，开展了本研究。采用细胞外皮质细胞记录以及α-IFN、吗啡和纳洛酮的微量离子导入法，同时还将这三种药物应用于同轴刺激的豚鼠回肠标本。应用α-IFN可引起皮质细胞和豚鼠回肠兴奋。相反，吗啡引起的主要效应是两种标本的活动均降低。纳洛酮能够逆转和/或预防两种标本中的吗啡效应，但未能改变α-IFN所诱导的效应。本研究利用豚鼠回肠标本和皮质神经元记录所得的观察结果，未能支持α-IFN效应是通过阿片受体介导的这一假设。
