Madsen B W, Edeson R O, Lam H S, Milne R K
Neurosci Lett. 1984 Jul 13;48(1):67-74. doi: 10.1016/0304-3940(84)90290-8.
A FORTRAN computer program is described which enables solution of a set of partial differential equations describing synaptic transmission, including neurotransmitter diffusion, binding to receptors on the postsynaptic membrane with subsequent formation of open ion-conducting channels, and hydrolysis. Integration is performed with a widely available package (PDETWO), and flexibility is achieved through use of 6 user-specified routines. The reliability of solution was checked by comparison with an analytic solution for a diffusion-only model. Application of the program is illustrated with an analysis of miniature endplate current rise times.
本文描述了一个FORTRAN计算机程序，它能够求解一组描述突触传递的偏微分方程，包括神经递质扩散、与突触后膜上的受体结合并随后形成开放的离子传导通道以及水解。使用一个广泛可用的软件包（PDETWO）进行积分，并通过使用6个用户指定的例程来实现灵活性。通过与仅扩散模型的解析解进行比较来检验解的可靠性。通过对微小终板电流上升时间的分析来说明该程序的应用。
