环磷酸鸟苷（cGMP）和环磷酸腺苷（cAMP）抑制去表皮冠状动脉的张力发展。
cGMP and cAMP inhibit tension development in skinned coronary arteries.
作者信息
Pfitzer G, Hofmann F, DiSalvo J, Rüegg J C
出版信息
Pflugers Arch. 1984 Jul;401(3):277-80. doi: 10.1007/BF00582596.
The effects of physiological concentrations of cGMP and cAMP on tension development in skinned coronary arteries (Triton X-100) were studied. cGMP inhibited tension elicited at intermediate Ca2+ concentrations at pH 7.0 but not at more acidic or alkaline pH values. cAMP, on the other hand, decreased submaximal tension development independent of pH (from pH 6.5 to pH 7.2). Neither nucleotide affected tension development at maximally activating Ca2+ concentrations.
研究了生理浓度的环鸟苷酸（cGMP）和环磷酸腺苷（cAMP）对经Triton X - 100处理的去内皮冠状动脉张力发展的影响。在pH 7.0时，cGMP抑制中等Ca2+浓度下引发的张力，但在更酸性或碱性pH值时则无此作用。另一方面，cAMP降低次最大张力发展，且与pH无关（pH范围从6.5至7.2）。在最大激活Ca2+浓度下，两种核苷酸均不影响张力发展。
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