Katsuura G, Hsiao S, Itoh S
Peptides. 1984 May-Jun;5(3):529-34. doi: 10.1016/0196-9781(84)90082-2.
An open field apparatus was used to assess the effect of proglumide, a selective antagonist of cholecystokinin octapeptide (CCK-8), to block the behavioral effect of CCK-8 in rats. Intracerebroventricular (ICV) injection of CCK-8 (0.5 to 2 micrograms) was effective in suppressing general exploratory activities and this effect was blocked by proglumide at doses of 2 to 5 micrograms administered ICV or 1 mg/kg administered subcutaneously. The effect of peripherally administered CCK-8 (10 micrograms/kg) was blocked by peripherally administered proglumide at a dose of 2 mg/kg but not by centrally administered proglumide at a dose of 5 micrograms/rat. The behavioral effect of CCK-8 was thus clearly blocked by proglumide.
采用旷场实验装置评估胆囊收缩素八肽（CCK-8）的选择性拮抗剂丙谷胺对大鼠CCK-8行为效应的阻断作用。脑室内（ICV）注射CCK-8（0.5至2微克）可有效抑制一般探索活动，而丙谷胺以2至5微克的剂量脑室内给药或1毫克/千克的剂量皮下给药可阻断这种效应。外周注射CCK-8（10微克/千克）的效应可被外周注射2毫克/千克的丙谷胺阻断，但不能被以5微克/大鼠的剂量脑内给药的丙谷胺阻断。因此，丙谷胺可明显阻断CCK-8的行为效应。
