Kopylov V A, Kuzin A M, Revin A F, Kutsyĭ M P
Radiobiologiia. 1984 Jul-Aug;24(4):516-9.
It was shown that gamma-radiation-induced oxidation of phenol compounds in the animal liver, which leads to o-dioxyphenols and quinones accretion, is one of the reasons for excluding cytochrome c from the respiratory chain of mitochondria. Radiochemical oxidation of tyrosil groups at the protein site of cytochrome c and, as a result, the restriction in the rate of reduction of the latter were noted. On the basis of the data obtained the authors discuss the mechanism of weakening the coupling of oxidation to phosphorylation upon irradiation and the molecular mechanism of the so-called cytochrome effect.
结果表明，γ辐射诱导动物肝脏中酚类化合物氧化，导致邻二酚和醌类物质增加，这是细胞色素c从线粒体呼吸链中被排除的原因之一。已观察到细胞色素c蛋白质位点上酪氨酸基团的放射化学氧化，结果限制了后者的还原速率。基于所获得的数据，作者讨论了辐射后氧化与磷酸化偶联减弱的机制以及所谓细胞色素效应的分子机制。
