Shyu B C, Andersson S A, Thorén P
Acta Physiol Scand. 1984 Jun;121(2):97-102. doi: 10.1111/j.1748-1716.1984.tb07434.x.
Earlier experiments have shown that afferent electrical stimulation of the sciatic nerve for 30 min induces a long-lasting post-stimulatory endorphin-dependent decrease in blood pressure in awake spontaneously hypertensive rats (SHR). In the present study we have examined whether this depressor response can be observed also in anesthetized SHR. The sciatic nerve was stimulated for 30 min with low-frequent (3 Hz) trains of impulses and the changes in blood pressure, heart rate and renal nerve activity were observed during the stimulation and in the post-stimulatory period. Animals anesthetized with Nembutal, Althesin and N2O did not show any post-stimulatory depression. In contrast, during chloralose anesthesia combined with muscle paralysis with Flaxedil, sciatic nerve stimulation induced a long-lasting post-stimulatory decrease in blood pressure due to central inhibition of sympathetic activity. The decrease in blood pressure could be prevented by naloxone and was therefore likely to be mediated via activation of central endorphin systems.
早期实验表明，对清醒的自发性高血压大鼠（SHR）的坐骨神经进行30分钟的传入电刺激，会诱导出一种持续时间较长的、依赖于刺激后内啡肽的血压下降。在本研究中，我们研究了在麻醉的SHR中是否也能观察到这种降压反应。用低频（3Hz）脉冲串刺激坐骨神经30分钟，并在刺激期间和刺激后观察血压、心率和肾神经活动的变化。用戊巴比妥、安泰酮和N2O麻醉的动物未表现出任何刺激后血压降低。相反，在氯醛糖麻醉并结合加拉碘铵进行肌肉麻痹的过程中，坐骨神经刺激由于交感神经活动的中枢抑制而导致刺激后血压长期下降。纳洛酮可以预防血压下降，因此这种下降可能是通过中枢内啡肽系统的激活介导的。
