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青蛙终板通道特性的季节性变化。

Seasonal changes in the properties of frog. End-plate channels.

作者信息

Lewis C A

出版信息

Biophys J. 1984 Aug;46(2):273-6. doi: 10.1016/S0006-3495(84)84021-7.

DOI:10.1016/S0006-3495(84)84021-7
PMID:6089926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1435030/
Abstract

The properties of the acetylcholine (ACh)-activated channel at the frog neuromuscular junction were studied using a two-microelectrode voltage clamp. The reversal potential was determined by interpolation of the ACh-induced current vs. voltage relation, while the single-channel conductance and the mean channel lifetime were calculated from fluctuation analysis of the mean ACh-induced end-plate current. Seasonal changes were observed in some of the measured parameters. While the reversal potential and the mean channel lifetime remained constant throughout the year, the single-channel conductance did not. The single-channel conductance was on the average 35% higher in the winter than in the summer. This effect could have survival value for hibernating frogs.

摘要

利用双微电极电压钳研究了青蛙神经肌肉接头处乙酰胆碱（ACh）激活通道的特性。通过对ACh诱导电流与电压关系进行插值来确定反转电位，而单通道电导和平均通道寿命则根据平均ACh诱导终板电流的波动分析来计算。在一些测量参数中观察到了季节性变化。虽然反转电位和平均通道寿命全年保持恒定，但单通道电导并非如此。冬季单通道电导平均比夏季高35%。这种效应可能对冬眠的青蛙具有生存价值。

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引用本文的文献

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本文引用的文献

1
Cardiac metabolism. IV. Seasonal variation; seasonal variation in metabolism and drug sensitivity of the isolated toad heart (Bufo marinus).心脏代谢。IV. 季节变化；离体海蟾蜍（Bufo marinus）心脏代谢及药物敏感性的季节变化
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2
Patch clamp studies of single ionic channels.单离子通道的膜片钳研究。
Annu Rev Biophys Bioeng. 1984;13:269-302. doi: 10.1146/annurev.bb.13.060184.001413.
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Seasonal changes in energy reserves in the common frog, Rana pipiens.
J Cell Physiol. 1965 Oct;66(2):251-8. doi: 10.1002/jcp.1030660212.
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An analysis of acetylcholine responses of junctional and extrajunctional receptors of frog muscle fibres.青蛙肌肉纤维终板和终板外受体的乙酰胆碱反应分析。
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The acetylcholine sensitivity in the vicinity of the neuromuscular junction of the frog.青蛙神经肌肉接头附近的乙酰胆碱敏感性。
Pflugers Arch. 1974 May 6;348(4):273-86. doi: 10.1007/BF00589217.
6
Electrical properties of toad sartorius muscle fibres in summer and winter.蟾蜍缝匠肌纤维在夏季和冬季的电特性
J Physiol. 1973 May;230(3):619-41. doi: 10.1113/jphysiol.1973.sp010208.
7
Ion-concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction.蛙神经肌肉接头处离子通道的反转电位和单通道电导的离子浓度依赖性。
J Physiol. 1979 Jan;286:417-45. doi: 10.1113/jphysiol.1979.sp012629.

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