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The mechanism of steroid anaesthetic (alphaxalone) block of acetylcholine-induced ionic currents.甾体麻醉剂（α-香树精）对乙酰胆碱诱导的离子电流的阻断机制。
Br J Pharmacol. 1984 Aug;82(4):783-9. doi: 10.1111/j.1476-5381.1984.tb16474.x.
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Interactions between molecules of a steroid anaesthetic (alphaxalone) and ionic channels of nodal membrane in voltage-clamped myelinated nerve fibre.甾体麻醉剂（α-香蒲甾醇）分子与电压钳制的有髓神经纤维节段膜离子通道之间的相互作用。
Br J Pharmacol. 1988 Jul;94(3):635-46. doi: 10.1111/j.1476-5381.1988.tb11570.x.
3
Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.甾体麻醉剂对培养大鼠脊髓神经元中γ-氨基丁酸激活的氯电导的增强作用。
J Physiol. 1987 May;386:485-501. doi: 10.1113/jphysiol.1987.sp016547.
4
Modulation of GABAA receptor activity by alphaxalone.α-香茅醇对GABAA受体活性的调节作用。
Br J Pharmacol. 1987 Mar;90(3):491-500. doi: 10.1111/j.1476-5381.1987.tb11198.x.
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Alphaxalone activates a Cl- conductance independent of GABAA receptors in cultured embryonic human dorsal root ganglion neurons.阿法沙龙可激活培养的人胚胎背根神经节神经元中一种独立于γ-氨基丁酸A型（GABAA）受体的氯离子电导。
J Neurophysiol. 1999 Jul;82(1):10-5. doi: 10.1152/jn.1999.82.1.10.
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Effects of drugs on acetylcholine-activated ionic channels of internally perfused chick myoballs.药物对内部灌注鸡肌球的乙酰胆碱激活离子通道的影响。
J Physiol. 1983 Apr;337:753-68. doi: 10.1113/jphysiol.1983.sp014653.
7
Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells.P物质可降低离体牛嗜铬细胞中乙酰胆碱诱导的电流。
J Physiol. 1984 Feb;347:255-77. doi: 10.1113/jphysiol.1984.sp015065.
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A neurosteroid anesthetic, alphaxalone, inhibits nicotinic acetylcholine receptors in cultured bovine adrenal chromaffin cells.一种神经甾体麻醉剂，α-香豆素，可抑制培养的牛肾上腺嗜铬细胞中的烟碱型乙酰胆碱受体。
Anesth Analg. 2002 Oct;95(4):900-6, table of contents. doi: 10.1097/00000539-200210000-00020.
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Kinetics of nicotinic acetylcholine ion channels in the presence of intravenous anaesthetics and induction agents.静脉麻醉药和诱导剂存在时烟碱型乙酰胆碱离子通道的动力学
Br J Pharmacol. 1992 Jul;106(3):623-7. doi: 10.1111/j.1476-5381.1992.tb14385.x.
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The neuroactive steroids alphaxalone and pregnanolone increase the conductance of single GABAA channels in newborn rat hippocampal neurons.神经活性甾体化合物阿法沙龙和孕烷醇酮可增加新生大鼠海马神经元中单个γ-氨基丁酸A型（GABAA）通道的电导。
J Steroid Biochem Mol Biol. 2007 Apr;104(1-2):35-44. doi: 10.1016/j.jsbmb.2006.09.042. Epub 2007 Jan 24.
引用本文的文献
1
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.映射原型五聚体配体门控离子通道 GLIC 中的两个神经甾体调制位点。
J Biol Chem. 2018 Feb 23;293(8):3013-3027. doi: 10.1074/jbc.RA117.000359. Epub 2018 Jan 4.
2
Modulation of GABAA receptor activity by alphaxalone.α-香茅醇对GABAA受体活性的调节作用。
Br J Pharmacol. 1987 Mar;90(3):491-500. doi: 10.1111/j.1476-5381.1987.tb11198.x.
3
Interactions between molecules of a steroid anaesthetic (alphaxalone) and ionic channels of nodal membrane in voltage-clamped myelinated nerve fibre.甾体麻醉剂（α-香蒲甾醇）分子与电压钳制的有髓神经纤维节段膜离子通道之间的相互作用。
Br J Pharmacol. 1988 Jul;94(3):635-46. doi: 10.1111/j.1476-5381.1988.tb11570.x.
4
Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.甾体麻醉剂对培养大鼠脊髓神经元中γ-氨基丁酸激活的氯电导的增强作用。
J Physiol. 1987 May;386:485-501. doi: 10.1113/jphysiol.1987.sp016547.
本文引用的文献
1
Steroid anaesthetics: inhibition of depolarization-secretion coupling at the mouse motor nerve terminal.类固醇麻醉剂：对小鼠运动神经末梢去极化-分泌偶联的抑制作用
Can J Physiol Pharmacol. 1980 Oct;58(10):1221-8. doi: 10.1139/y80-185.
2
Comparison of desensitization and time-dependent block of the acetylcholine receptor responses by chlorpromazine, cytochalasin B, triton X-100 and other agents.氯丙嗪、细胞松弛素B、曲拉通X-100及其他试剂对乙酰胆碱受体反应的脱敏作用和时间依赖性阻断的比较
Br J Pharmacol. 1980 May;69(1):99-106. doi: 10.1111/j.1476-5381.1980.tb10887.x.
3
The kinetics of local anesthetic blockade of end-plate channels.局部麻醉药对终板通道的阻滞动力学。
Biophys J. 1982 Mar;37(3):625-31.
4
Additive and non-additive effects of mixtures of short-acting intravenous anaesthetic agents and their significance for theories of anaesthesia.短效静脉麻醉剂混合物的相加和非相加作用及其对麻醉理论的意义。
Br J Pharmacol. 1981 Sep;74(1):161-70. doi: 10.1111/j.1476-5381.1981.tb09969.x.
5
Quinacrine (mepacrine) action at frog end-plate.喹吖因（米帕林）对蛙终板的作用。
J Physiol. 1980 Sep;306:261-81. doi: 10.1113/jphysiol.1980.sp013396.
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Action of some steroids on the centtral nervous system of the mouse. II. Pharmacology.某些类固醇对小鼠中枢神经系统的作用。II. 药理学
J Med Chem. 1965 Jul;8(4):426-32. doi: 10.1021/jm00328a004.
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Extrinsic and intrinsic acetylcholine and barbiturate effects on frog skeletal muscle.外源性和内源性乙酰胆碱及巴比妥酸盐对青蛙骨骼肌的作用。
Br J Pharmacol. 1970 Nov;40(3):552P-553P.
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On the mechanism of desensitization at cholinergic receptors.关于胆碱能受体脱敏的机制
Mol Pharmacol. 1970 Jul;6(4):357-82.
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The statistical nature of the acetycholine potential and its molecular components.乙酰胆碱电位及其分子成分的统计学性质。
J Physiol. 1972 Aug;224(3):665-99. doi: 10.1113/jphysiol.1972.sp009918.
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The membrane actions of anesthetics and tranquilizers.麻醉剂和镇静剂的膜作用。
Pharmacol Rev. 1972 Dec;24(4):583-655.
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