Ahrén B, Lundquist I
Eur J Pharmacol. 1984 Jun 15;102(1):135-9. doi: 10.1016/0014-2999(84)90346-7.
Endogenous opiates have been suggested to have effects on insulin secretion. In order to investigate the in vivo importance of endogenous opiate receptor agonists on basal and stimulated insulin secretion, the effect on plasma insulin of opiate receptor blockade by naloxone was studied in the mouse. It was found that the plasma insulin levels in naloxone-injected mice were moderately lower than in the control animals after 5 min. Ten minutes later, however, naloxone-injected animals had slightly higher plasma insulin levels than did the controls. Naloxone moderately potentiated the insulin secretory responses to glucose and the beta 2-adrenoceptor agonist terbutaline. On the contrary, naloxone had no apparent effect on the insulin secretory response to the cholinergic agonist carbachol or the synthetic C-terminal octapeptide of cholecystokinin, CCK-8. In conclusion, endogenous opioid substances might moderate the regulation of basal insulin levels in the mouse. Further, they seem to have the capability to modulate the insulin release stimulated by glucose or beta-adrenoceptor agonists.
内源性阿片类物质被认为对胰岛素分泌有影响。为了研究内源性阿片受体激动剂对基础和刺激胰岛素分泌的体内重要性，在小鼠中研究了纳洛酮对阿片受体的阻断作用对血浆胰岛素的影响。发现注射纳洛酮的小鼠在5分钟后血浆胰岛素水平略低于对照动物。然而，10分钟后，注射纳洛酮的动物血浆胰岛素水平略高于对照动物。纳洛酮适度增强了对葡萄糖和β2 -肾上腺素能受体激动剂特布他林的胰岛素分泌反应。相反，纳洛酮对胆碱能激动剂卡巴胆碱或胆囊收缩素的合成C末端八肽CCK - 8的胰岛素分泌反应没有明显影响。总之，内源性阿片类物质可能调节小鼠基础胰岛素水平。此外，它们似乎有能力调节由葡萄糖或β -肾上腺素能受体激动剂刺激的胰岛素释放。
