哌仑哌隆体内活性中可能存在的α2-肾上腺素能成分。
A possible alpha 2-adrenergic component in the in vivo activity of pirenperone.
作者信息
Colpaert F C, Janssen P A
出版信息
Eur J Pharmacol. 1984 Aug 3;103(1-2):169-71. doi: 10.1016/0014-2999(84)90206-1.
PMID:6090171
Abstract
The study used the loss of the righting reflex in response to the alpha 2-agonist xylazine in an in vivo rat assay to determine possible effects of the LSD antagonist pirenperone at alpha 2-adrenoceptors. Pirenperone antagonized the response and was more potent (ED50: 0.32 mg/kg) than yohimbine (1.25 mg/kg) and piperoxan (3.30 mg/kg). The data suggest that pirenperone may act at alpha 2-adrenoceptors in vivo.
摘要
该研究在体内大鼠试验中利用对α2-激动剂赛拉嗪的翻正反射丧失来确定LSD拮抗剂匹泮哌隆对α2-肾上腺素能受体可能产生的影响。匹泮哌隆可拮抗该反应，且比育亨宾（1.25mg/kg）和哌泊昔生（3.30mg/kg）更有效（半数有效剂量：0.32mg/kg）。数据表明匹泮哌隆可能在体内作用于α2-肾上腺素能受体。
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