Seliverstov G A
Farmakol Toksikol. 1984 Jul-Aug;47(4):46-51.
The effects of the non-inhalation anesthetics, ketamine and hexenal (25 and 100 microM/l) on excitable membranes of the frog sartorius muscle were studied with the aid of intra- and extracellular electrodes. At the concentration 100 microM the anesthetics depressed most markedly the junctional transmission and practically had no influence on motor axon function. Since ketamine did not interact evidently with tubocurarine and showed pronounced antagonism to Mg ions, it is assumed that ketamine interferes with neuronally induced transmitter release.
使用细胞内和细胞外电极，研究了非吸入性麻醉剂氯胺酮和己烯醛（25和100微摩尔/升）对青蛙缝匠肌可兴奋膜的影响。在100微摩尔的浓度下，麻醉剂最显著地抑制了接头传递，而对运动轴突功能几乎没有影响。由于氯胺酮与筒箭毒碱没有明显相互作用，且对镁离子表现出明显的拮抗作用，因此推测氯胺酮会干扰神经元诱导的递质释放。
