Ksenzenko M, Konstantinov A A, Khomutov G B, Tikhonov A N, Ruuge E K
FEBS Lett. 1984 Sep 17;175(1):105-8. doi: 10.1016/0014-5793(84)80579-7.
The rate of the antimycin-induced H2O2 and O(2) generation in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of approximately 1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at Eh values more positive than the optimal. The modulation of O(2) and H2O2 generation by these inhibitors can be explained by their effects on the steady-state redox potential(s) of the component(s) of mitochondrial site 2.
抗霉素诱导的牛心亚线粒体颗粒中H2O2和O(2)生成速率在[琥珀酸]/[延胡索酸]比值约为1:5时最大，并在较高和较低的氧化还原电位下均下降。琥珀酸脱氢酶抑制剂，如TTFA或丙二酸，在存在过量琥珀酸时会刺激活性氧的产生，但在比最佳值更正的Eh值下具有抑制作用。这些抑制剂对O(2)和H2O2生成的调节作用可以通过它们对线粒体2位点组分的稳态氧化还原电位的影响来解释。
