Wong T M, Tse S Y
Int J Pept Protein Res. 1984 Jul;24(1):74-8. doi: 10.1111/j.1399-3011.1984.tb00930.x.
beta-endorphin administered intraventricularly into pentobarbital anaesthetized rats led to a reduction in rectal temperature and a dose dependent biphasic response in metabolic rate with increase at low doses (7-10 nmol/kg) and decrease at high doses (30-300 nmol/kg) in rats acclimated to 22 degrees. These metabolic responses to beta-endorphin were enhanced both in magnitude and in duration in rats acclimated to 5 degrees for 3 weeks, indicating an increased responsiveness to beta-endorphin. Naloxone antagonized the metabolic effects of beta-endorphin in rats acclimated to both 22 degrees and 5 degrees, indicating the metabolic effects of beta-endorphin were via the naloxone sensitive opiate receptors.
向戊巴比妥麻醉的大鼠脑室内注射β-内啡肽，会导致直肠温度降低，且在适应22摄氏度的大鼠中，代谢率呈剂量依赖性双相反应，低剂量（7-10纳摩尔/千克）时升高，高剂量（30-300纳摩尔/千克）时降低。在适应5摄氏度3周的大鼠中，这些对β-内啡肽的代谢反应在幅度和持续时间上均增强，表明对β-内啡肽的反应性增加。纳洛酮拮抗了适应22摄氏度和5摄氏度大鼠中β-内啡肽的代谢作用，表明β-内啡肽的代谢作用是通过对纳洛酮敏感的阿片受体介导的。
