Wolf G L, Fobben E S
Invest Radiol. 1984 Jul-Aug;19(4):324-8. doi: 10.1097/00004424-198407000-00017.
Three different doses of gadolinium (Gd) DTPA were administered intravenously to rabbits. Cardiovascular responses and changes in blood T1 and T2 were serially followed for 15 minutes when the animals were sacrificed for in vitro measures of tissue T1 and T2. Gd-DTPA was distributed and excreted like water soluble iodinated contrast agents with large changes in blood, urine, and kidney proton relaxation. An imaging experiment confirmed the efficacy as an NMR contrast agent for renal excretion. At effective doses, no adverse effects were observed and the agent appeared to be much safer than x-ray contrast agents, but with a similar potential for clinical utility.
将三种不同剂量的钆（Gd）二乙三胺五乙酸（DTPA）静脉注射给兔子。在处死动物以进行组织T1和T2的体外测量时，连续15分钟跟踪心血管反应以及血液T1和T2的变化。钆二乙三胺五乙酸的分布和排泄类似于水溶性碘化造影剂，血液、尿液和肾脏中的质子弛豫有很大变化。一项成像实验证实了其作为用于肾脏排泄的核磁共振造影剂的有效性。在有效剂量下，未观察到不良反应，且该造影剂似乎比X射线造影剂安全得多，但具有相似的临床应用潜力。
