Lawlor K M, Payne S M
J Bacteriol. 1984 Oct;160(1):266-72. doi: 10.1128/jb.160.1.266-272.1984.
Aerobactin, a hydroxamate iron transport compound, is synthesized by some, but not all, Shigella species. Conjugation and hybridization studies indicated that the genes for the synthesis and transport of aerobactin are linked and are found on the chromosome of Shigella flexneri, S. boydii, and S. sonnei. The genes were not found in S. dysenteriae. A number of aerobactin synthesis mutants and transport mutants have been isolated. The most common mutations are deletions of the biosynthesis or biosynthesis and transport genes. The Shigella aerobactin genes share considerable homology with the E. coli ColV aerobactin genes. On the ColV plasmid and in the Shigella chromosome, the aerobactin genes are associated with a repetitive sequence which has been identified as IS1.
气杆菌素是一种异羟肟酸铁转运化合物，部分（而非全部）志贺氏菌属细菌能够合成该物质。接合和杂交研究表明，气杆菌素的合成和转运基因是连锁的，并且位于弗氏志贺氏菌、鲍氏志贺氏菌和宋内氏志贺氏菌的染色体上。痢疾志贺氏菌中未发现这些基因。已经分离出许多气杆菌素合成突变体和转运突变体。最常见的突变是生物合成或生物合成与转运基因的缺失。志贺氏菌的气杆菌素基因与大肠杆菌ColV气杆菌素基因具有相当高的同源性。在ColV质粒和志贺氏菌染色体上，气杆菌素基因与一个已被鉴定为IS1的重复序列相关。
