Stahl S M
J Clin Psychiatry. 1984 Oct;45(10 Pt 2):37-45.
Recent findings on neurotransmitter receptors are reviewed as they relate to current hypotheses of the etiology of depression and mechanism of action of antidepressant drugs. Two important research areas are 1) the finding that each synapse may have more than one neurotransmitter, and 2) data which link specific neurotransmitters and receptors to depressive illness and antidepressant drug response. A new hypothesis that has emerged from receptor studies is the neurotransmitter receptor hypothesis of antidepressant reaction, which states that antidepressants exert their effects by down-regulating neurotransmitter receptors. Research questions generated by these hypotheses are reviewed, and implications of findings in this area for the development of more effective, rapid-acting antidepressants are discussed.
本文综述了神经递质受体的最新研究成果，这些成果与当前关于抑郁症病因和抗抑郁药物作用机制的假说相关。两个重要的研究领域是：1）发现每个突触可能不止有一种神经递质；2）将特定神经递质和受体与抑郁症及抗抑郁药物反应联系起来的数据。受体研究中出现的一个新假说是抗抑郁反应的神经递质受体假说，该假说认为抗抑郁药通过下调神经递质受体发挥作用。本文对这些假说引发的研究问题进行了综述，并讨论了该领域研究结果对开发更有效、起效更快的抗抑郁药物的意义。
