Peterson L L, Shaw J C, Acott K M, Mueggler P A, Parker F
J Am Acad Dermatol. 1984 Sep;11(3):468-73. doi: 10.1016/s0190-9622(84)70192-7.
A 63-year-old white woman with perioral dermatitis, a sore tongue, and an erythematous dermatosis in the inframammary and perineal regions underwent surgical removal of a pancreatic glucagonoma. The patient's plasma and pooled normal human plasma containing Sigma glucagon were fed to human keratinocyte cultures and increased arachidonic acid levels by 300% and 200%, respectively, when compared to pooled normal human plasma with no added commercial glucagon. These experiments suggest that glucagon may increase inflammatory mediators such as arachidonic acid and its metabolites in the epidermis, causing the skin lesions seen in the glucagonoma syndrome.
一名63岁的白人女性，患有口周皮炎、舌痛以及乳房下和会阴区的红斑性皮肤病，接受了胰腺高血糖素瘤切除术。将该患者的血浆以及含有Sigma高血糖素的正常人混合血浆加入人角质形成细胞培养物中，与未添加商业高血糖素的正常人混合血浆相比，花生四烯酸水平分别升高了300%和200%。这些实验表明，高血糖素可能会增加表皮中花生四烯酸及其代谢产物等炎症介质，从而导致高血糖素瘤综合征中出现的皮肤病变。
