• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

羧酸离子载体可增强配体和抗体递送的蓖麻毒素A链的细胞毒性效力。

Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.

作者信息

Raso V, Lawrence J

出版信息

J Exp Med. 1984 Oct 1;160(4):1234-40. doi: 10.1084/jem.160.4.1234.

DOI:10.1084/jem.160.4.1234
PMID:6090575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187464/
Abstract

The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is correspondingly increased by several orders of magnitude and cells that sparsely express the target antigen or receptor can be killed.

摘要

位点导向的蓖麻毒素A链缀合物的高选择性细胞毒性可被膜活性羧酸离子载体增强。这两种药物联合使用会使核糖体更快失活，随后导致细胞死亡和裂解。A链细胞毒素的效力相应提高了几个数量级，并且稀疏表达靶抗原或受体的细胞也能被杀死。

相似文献

1
Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.羧酸离子载体可增强配体和抗体递送的蓖麻毒素A链的细胞毒性效力。
J Exp Med. 1984 Oct 1;160(4):1234-40. doi: 10.1084/jem.160.4.1234.
2
Enhancement of ricin toxin A chain immunotoxin activity: synthesis, ionophoretic ability, and in vitro activity of monensin derivatives.
Biochem Pharmacol. 1996 Jul 12;52(1):157-66. doi: 10.1016/0006-2952(96)00176-1.
3
Potent cytotoxicity of an antihuman transferrin receptor-ricin A-chain immunotoxin on human glioma cells in vitro.抗人转铁蛋白受体-蓖麻毒素A链免疫毒素对人胶质瘤细胞的体外强细胞毒性
Cancer Res. 1990 Oct 15;50(20):6696-700.
4
Enhancement of the cytotoxic effect of anti-carcinoembryonic antigen immunotoxins by adenovirus and carboxylic ionophores.腺病毒和羧酸离子载体增强抗癌胚抗原免疫毒素的细胞毒性作用
J Natl Cancer Inst. 1987 Oct;79(4):679-85.
5
Intracellular pathways of ricin A chain cytotoxins.蓖麻毒素A链细胞毒素的细胞内途径。
Ann N Y Acad Sci. 1987;507:172-86. doi: 10.1111/j.1749-6632.1987.tb45800.x.
6
Assessment of ligand effects in intracellular trafficking of ricin A chain using anti-ricin hybridomas.利用抗蓖麻毒素杂交瘤评估蓖麻毒素A链细胞内运输中的配体效应。
Cancer Res. 1991 Mar 15;51(6):1689-93.
7
Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.免疫毒素诱导的细胞毒性动力学。溶酶体促效胺和羧酸离子载体的增强作用。
J Biol Chem. 1984 Aug 10;259(15):9359-64.
8
Recombinant ricin A chain conjugated to monoclonal antibodies: improved tumor cell inhibition in the presence of lysosomotropic compounds.与单克隆抗体偶联的重组蓖麻毒素A链：在溶酶体促渗剂存在下增强肿瘤细胞抑制作用
Cancer Res. 1989 Feb 1;49(3):613-7.
9
Selective killing of human T-lymphotropic virus-I infected leukemic T-cells by monoclonal anti-interleukin 2 receptor antibody-ricin A chain conjugates: potentiation by ammonium chloride and monensin.单克隆抗白细胞介素2受体抗体-蓖麻毒素A链偶联物对人嗜T淋巴细胞病毒-I感染的白血病T细胞的选择性杀伤作用：氯化铵和莫能菌素的增强作用
Cancer Res. 1986 Jul;46(7):3295-8.
10
Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma.腹腔内免疫毒素在人恶性间皮瘤裸鼠模型中的抗肿瘤活性。
Cancer Res. 1987 Aug 15;47(16):4266-70.

引用本文的文献

1
Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers.通过内体逃逸增强剂提高免疫毒素和其他靶向蛋白毒素的疗效
Toxins (Basel). 2016 Jul 1;8(7):200. doi: 10.3390/toxins8070200.
2
Potential therapeutic applications of plant toxin-ricin in cancer: challenges and advances.植物毒素蓖麻毒素在癌症治疗中的潜在应用：挑战与进展
Tumour Biol. 2015 Nov;36(11):8239-46. doi: 10.1007/s13277-015-4028-4. Epub 2015 Sep 9.
3
Characterization of the increased cytotoxicity of gelonin anti-T cell immunoconjugates compared with ricin A chain immunoconjugates.与蓖麻毒素A链免疫缀合物相比，相思子毒素抗T细胞免疫缀合物细胞毒性增加的特性
Clin Exp Immunol. 1994 Jul;97(1):10-8. doi: 10.1111/j.1365-2249.1994.tb06572.x.

本文引用的文献

1
Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells.致死剂量的相思子毒素、蓖麻毒素和莫德菌素进入HeLa细胞的细胞质。
Exp Cell Res. 1980 Apr;126(2):321-6. doi: 10.1016/0014-4827(80)90270-0.
2
Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.对携带常见急性淋巴细胞白血病抗原的细胞具有选择性细胞毒性的单克隆抗体-蓖麻毒素A链缀合物。
Cancer Res. 1982 Feb;42(2):457-64.
3
Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells.含蓖麻毒素A链免疫毒素与含蓖麻毒素B链免疫毒素在体外杀伤人类肿瘤性B细胞中的协同作用。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6332-5. doi: 10.1073/pnas.80.20.6332.
4
A highly cytotoxic human transferrin-ricin A chain conjugate used to select receptor-modified cells.一种用于筛选受体修饰细胞的高细胞毒性人转铁蛋白-蓖麻毒素A链偶联物。
J Biol Chem. 1984 Jan 25;259(2):1143-9.
5
Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.腺病毒增强抗转铁蛋白受体抗体-铜绿假单胞菌外毒素偶联物的毒性
Proc Natl Acad Sci U S A. 1983 Jul;80(13):4134-8. doi: 10.1073/pnas.80.13.4134.
6
pH and the recycling of transferrin during receptor-mediated endocytosis.pH与受体介导的内吞作用过程中转铁蛋白的循环利用
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2258-62. doi: 10.1073/pnas.80.8.2258.
7
Receptor-mediated endocytosis of transferrin in K562 cells.转铁蛋白在K562细胞中的受体介导内吞作用。
J Biol Chem. 1983 Apr 25;258(8):4715-24.
8
Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.蓖麻毒素-抗Thy 1.1单克隆抗体杂交体使蛋白质合成失活的动力学。通过重组证明蓖麻毒素B亚基的作用。
J Biol Chem. 1982 Feb 25;257(4):1598-601.
9
Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains.有毒凝集素相思子毒素和蓖麻毒素对核糖体的失活作用。毒素A链酶活性的动力学研究。
Eur J Biochem. 1975 Dec 1;60(1):281-8. doi: 10.1111/j.1432-1033.1975.tb21001.x.
10
Biological applications of ionophores.离子载体的生物学应用。
Annu Rev Biochem. 1976;45:501-30. doi: 10.1146/annurev.bi.45.070176.002441.