Role of corpus callosum in functional organization of cat striate cortex.

The short-term (3-51 days) and long-term (31-42 wk) effects of corpus callosum transection on the receptive-field properties of neurons were assessed at the single-cell, architectural, and topographical levels of organization in the cat striate cortex. Corpus callosum transection decreased the proportion of neurons that could be activated from both eyes. In short-term animals, the reduction in binocularity was restricted to the representation of a vertical strip of visual space extending from the vertical meridian to at least 12 degrees lateral. In the long-term animals, the reduction in binocularity was restricted to the representation of visual space 4 degrees lateral to the vertical meridian. Therefore, the reduction in the representation of 4-12 degrees was only temporary. In both groups, the reduction in binocularity was less in the representation of area centralis than at other retinal locations in the same vertical strip. The region of area 17 affected permanently by the transection receives fibers from the contralateral hemisphere in normal animals. The region affected temporarily by the transection contains callosal cells but does not contain callosal terminals. Binocularity was assessed separately for simple I, simple II, and complex receptive-field types. The reduction in binocularity in the 12 degrees strip in short-term animals and in the 4 degrees strip in long-term animals was accounted for mainly by a reduction in binocularity of simple I and complex cells. As in normal animals, complex cells in callosum-transected cats were always more binocular than the other cell types. An analysis of the effects of corpus callosum transection on different cortical layers showed that a greater proportion of cells in the supragranular layers II and III showed a reduction in binocularity than in the infragranular layers V and VI. The proportion of binocular neurons in layer IV was not significantly different from normal. The major decreases in binocularity occurred in layers II, III, and VI for simple I and simple II cells and in layers II, III, and V for complex cells. The binocularity of simple II cells in layer IV and complex cells in layer VI was not affected. The effects of the transection on the columnar organization of the cortex were assessed by making electrode tracks that passed in the radial or laminar dimensions of the cortex. Reconstructions of the radial tracks showed that cells within one radial column tended to be dominated by the same eye. In adjacent columns, cells tended to be dominated by different eyes.(ABSTRACT TRUNCATED AT 400 WORDS)