Lerner-Natoli M, Rondouin G, Baldy-Moulinier M
J Neurosci Res. 1984;12(1):101-11. doi: 10.1002/jnr.490120110.
Kindling patterns were compared in different regions of the hippocampus of the rat. The duration, morphology, and frequency of the electrical responses were different after stimulation of the dorsal and the ventral hippocampus, but these parameters showed the same evolution as kindling progressed. Comparison of the threshold intensity and of the kindling rate revealed some differences not only between dorsal and ventral hippocampus, but also within the dorsal hippocampus: The central layers had higher thresholds and longer kindling periods than the outer layers and the fimbria hippocampi. We suggest that stimulation of hippocampal efferents is responsible for the greater ease of kindling in the outer layers than in the central regions of this structure. The degree of connection of the different parts of the hippocampus with the amygdala and the influence of the intrinsic inhibitory GABAergic circuitry are discussed.
对大鼠海马不同区域的点燃模式进行了比较。刺激背侧和腹侧海马后，电反应的持续时间、形态和频率有所不同，但随着点燃过程的进展，这些参数呈现出相同的演变。阈值强度和点燃率的比较不仅揭示了背侧和腹侧海马之间的一些差异，也揭示了背侧海马内部的差异：中央层比外层和海马伞具有更高的阈值和更长的点燃期。我们认为，海马传出纤维的刺激是该结构外层比中央区域更容易点燃的原因。讨论了海马不同部分与杏仁核的连接程度以及内在抑制性GABA能回路的影响。
