Tigranian R A, Vakulina O P, Panchenko L F
Kosm Biol Aviakosm Med. 1984 Jul-Aug;18(4):63-6.
The content of methionine-enkephalin, leucine-enkephalin and beta-endorphine was measured in various brain compartments (hypophysis, hypothalamus, midbrain, medulla oblongata, striatum), adrenals and plasma of the rats exposed to single and repeated immobilization. The reaction of the opiate systems to immobilization was very distinct in the emotiogenic brain structures (hypothalamus and midbrain) and hypophysis. The content of opiate-like peptides varied as a function of the immobilization time, with the most distinct changes occurring at the 150th minute. After daily immobilization repeated 40 times adaptation to the chronic stress-effect developed.
对单次和重复固定的大鼠的各种脑区（垂体、下丘脑、中脑、延髓、纹状体）、肾上腺和血浆中的甲硫氨酸脑啡肽、亮氨酸脑啡肽和β-内啡肽含量进行了测定。阿片系统对固定的反应在情绪发生脑结构（下丘脑和中脑）和垂体中非常明显。阿片样肽的含量随固定时间而变化，在第150分钟时变化最为明显。每天重复固定40次后，机体对慢性应激效应产生了适应性。
