Carlson H E
Life Sci. 1984 Oct 22;35(17):1747-54. doi: 10.1016/0024-3205(84)90271-6.
Nickel (Ni++) is a potent inhibitor of prolactin (PRL) secretion from isolated rat pituitary quarters in vitro, suppressing both basal PRL release and the stimulation of PRL secretion due to theophylline and dibutyryl cyclic AMP. Stimulation of growth hormone (GH) secretion by synthetic GHRH is also blunted by Ni++, although basal GH release and stimulated GH release due to theophylline or dibutyryl cyclic AMP are not suppressed. Ni++ antagonizes the stimulation of both PRL and GH secretion by barium (Ba++) ion, suggesting that the inhibitory effects of Ni++ on hormone release are due to an antagonism of calcium uptake or redistribution.
镍离子（Ni++）是体外分离的大鼠垂体切片催乳素（PRL）分泌的有效抑制剂，可抑制基础PRL释放以及由茶碱和二丁酰环磷酸腺苷引起的PRL分泌刺激。尽管基础生长激素（GH）释放以及由茶碱或二丁酰环磷酸腺苷引起的GH释放刺激未受抑制，但合成的生长激素释放激素（GHRH）对GH分泌的刺激也会被Ni++减弱。Ni++拮抗钡离子（Ba++）对PRL和GH分泌的刺激作用，这表明Ni++对激素释放的抑制作用是由于对钙摄取或再分布的拮抗作用。
