Medina J H, Wolfman C, Levi de Stein M, Tumilasci O, Houssay A B
Life Sci. 1984 Aug 20;35(8):819-25. doi: 10.1016/0024-3205(84)90406-5.
The effects of altered thyroid function on the sensitivity of isoproterenol induced secretion of saliva and in the characteristics of adrenergic receptors from the rat submandibular gland were examined. Hyperthyroidism produced an increased sensitivity to beta-adrenergic stimulation of the gland, and this phenomenon was associated with an increase in the number of beta and alpha 1-adrenoceptors. On the other hand, surgical thyroidectomy produced a decrease sensitivity to isoproterenol stimulation of the submandibular gland and a diminished density of beta-adrenoceptors. In this case, no changes in alpha-adrenoceptors were observed. These results are discussed emphasizing the correlation between the functional control of saliva secretion and the adrenergic receptors in different thyroid states.
研究了甲状腺功能改变对异丙肾上腺素诱导大鼠颌下腺唾液分泌敏感性及肾上腺素能受体特性的影响。甲状腺功能亢进导致腺体对β-肾上腺素能刺激的敏感性增加，这一现象与β和α1-肾上腺素能受体数量的增加有关。另一方面，手术切除甲状腺导致颌下腺对异丙肾上腺素刺激的敏感性降低以及β-肾上腺素能受体密度降低。在这种情况下，未观察到α-肾上腺素能受体的变化。讨论了这些结果，强调了不同甲状腺状态下唾液分泌的功能控制与肾上腺素能受体之间的相关性。
